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Article: Vegan “Collagen”: What really works

Veganes „Kollagen“: Was wirklich wirkt
BEAUTY

Vegan “Collagen”: What really works

Collagen – why it is so important for skin, bones & connective tissue

Collagen is the most abundant protein in the human body. It forms fibrous structures that make skin, bones, tendons, cartilage, and blood vessels both stable and elastic. Its characteristic feature is the triple helix , composed of chains rich in glycine, proline, and hydroxyproline. With age, its production and quality decline—visible through loss of elasticity, wrinkles, and drier skin. *

What is collagen – and what benefits does research show?

"Collagen" in dietary supplements is usually hydrolyzed collagen peptides (of animal origin) that are broken down into peptides/amino acids in the intestine. RCTs and meta-analyses report improvements in skin hydration, elasticity, and fine wrinkles after 4–12 weeks of supplementation. The effects are moderate but reproducible. **

Collagen production & skin elasticity: influencing factors

For endogenous (body’s own) collagen synthesis, the following are necessary:

  • Vitamin C is an essential cofactor for prolyl/lysyl hydroxylases (key to stable collagen helix). A deficiency slows collagen maturation; ascorbate can also stimulate collagen gene expression. ***

  • Amino acids (especially glycine, proline, lysine). They provide the basic structure of the triple helix. ****

  • UV radiation, oxidative stress, glycation, lack of sleep – all of these accelerate collagen degradation; antioxidants and lifestyle counteract this.

Is there “collagen for vegans”?

Plants don't produce collagen. "Vegan collagen" therefore usually refers to collagen boosters (nutrients that support the body's own production). At the same time, animal-free, fermentatively produced collagens (recombinant/animal-free) are being developed from yeast/bacteria or plant cell factories – currently available primarily in cosmetics; these are still rarely used as dietary supplements .

How does “vegan collagen” (booster) work?

Goal: Provide building blocks & cofactors, slow down collagen degradation.

  • Vitamin C – Mechanism: Cofactor of hydroxylases, supports stable collagen fibrils. EU Health Claim: "Contributes to normal collagen formation for the normal function of the skin ."
  • Amino acids (glycine, proline, lysine) – Mechanism: Structural building blocks of the triple helix; sufficient protein supply is the basis.
  • Hyaluronic acid (HA) Oral: RCTs show increased skin hydration after 2–12 weeks. (HA is not collagen, but supplements the skin's extracellular matrix.)
  • Plant extracts/mineral substances – Silicon (e.g., from bamboo/orthosilicic acid compounds): Studies indicate improvements in skin microrelief, elasticity, and hair/nail parameters when taken orally. ***** Centella asiatica (Cica/Gotu Kola): Stimulates fibroblasts and collagen synthesis ; clinical evidence is growing, although heterogeneous.


    Vitamin C – the central lever

    Vitamin C is biochemically irreplaceable for collagen maturation. Without ascorbate, proline/lysine are not sufficiently hydroxylated, and the helix remains unstable. Therefore, vitamin C is a mandatory ingredient in "vegan collagen concepts." (See above for the EU claim for skin/collagen.)

    Food sources (suitable for everyday use):
    Peppers, citrus fruits, berries, broccoli, kale, kiwis – combined with sufficient protein (e.g. legumes, tofu/tempeh, oats, seeds/nuts) to provide the necessary amino acids.

    Animal vs. vegan collagen – what does the evidence say?

    • Animal collagen peptides: solid RCT evidence for skin hydration/elasticity and fine wrinkles; not vegan.

    • Vegan "collagen boosters" : provide cofactor building blocks (vitamin C, amino acids, silicon, phytochemicals). The evidence is more indirect, based on mechanisms and studies on individual components (e.g., vitamin C claims; silicon RCTs; HA RCTs).

    • Fermentatively produced, “animal-free” collagen : technologically available (cosmetics), not yet standard in food supplements.

    Short conclusion

    Those who live a vegan lifestyle make sense by relying on booster concepts (vitamin C + protein/amino acids + silicon + HA + antioxidant plant compounds). Those who accept animal peptides can benefit from direct effects—the decision is ethically/nutritional.

    Product recommendations:

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